Commercial name: Erythrocin 250 ,500 mg tab, 100mg/5ml susp,100mg/ml ped. drops;
Etrocin, Eryster: 250mg tab, 100mg/5ml dry syp, Emthro250mg tab, 125mg/5ml suspension.
Acts by inhibiting bacterial protein synthesis. It interferes with 50 S ribosome
sub units and interferes with translocation.
-
Alternative to penicillin G and other penicillins for the treatment of patients
hypersensitive to penicillin.
-
Treatment of upper and lower respiratory tract, skin and soft tissue infections
of mild to moderate severity.
- As a first choice of drugs for atypical pneumonia and whooping cough.
- Psuedomembranous colitis and hepatic dysfunction reported.
- Contraindicated in concomitant terfenadine.
-
Nausea, vomiting, diarrhoea, anorexia, abdominal pain, hepatic dysfunction, abnormal
LFTs, allergic reactions and superinfection.
Commercial name: Claribid 250, 500 mg tab, 250mg/5ml dry syp; Clarimac 250, 500mg
tabs.
Acts by inhibiting bacterial protein synthesis. It interferes with 50S ribosome
sub units and interferes with translocation.
-
Treatment of upper and lower respiratory tract infections, sinusitis, otitis media,
atypical pneomonia skin and skin structure infections due to strp. pyogenes and
staph. aureus.
-
It is the first line of treatment in MAC infections in AIDS patients and second
line of treatment for other atypical mycobacteria diseases in leprosy patients.
-
W/P: Avoid in pregnancy. Psuedomembranous colitis reported. Adjust dose with severe
renal impairment.
- Contraindicated in concomitant cisapride, pimozide, terfenadine.
-
Nausea, diarrhoea, abnormal taste, dyspepsia, abdominal pain, headache, vomiting,
rash.
Commercial name: Azithral 250, 500mg cap and 250 mg /5ml dry syr; Aziwok 250 mg
cap, 100mg, 100mg/5ml and 200mg/5ml susp.; Aziwin 100, 250, 500 mg tab.
Acts by inhibiting bacterial protein synthesis. It interferes with 50S ribosome
sub units and interferes with translocation.
-
It is the first choice of treatment in Legionairre's pneumonia, Chalymidial tracomatis.
-
Other indications include pharyngitis, tonsillitis, sinusitis, acute exacerbations
of chronic bronchitis, streptococcal and some staphylococcal skin and soft tissue
infections and gonorrhea.
-
Monitor theophylline terfenadine, cyclosporine, phenytoin and warfarin. May increase
digoxin and carbamazepine level.
- Mild gastric upset, abdominal pain headache and dizziness.
