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Agents Affecting Salivation

Saliva plays a vital role in protecting the soft and the hard tissues and in such functions as taste, mastication and deglutition. Excessive saliva can however complicate the performance of dental procedures. Chronic hypersalivation can cause psychological problems and both local and systemic disorders.

Special dental considerations

  • To control salivation when performing restorative dentistry, the dentist should time the drug administration so that the peak effect occurs when the dry operation is most needed. Thus, anticholinergics should be given 60-90 minutes before taking the impression or placement of restorations.The analogues of glycopyrrolate or propanthaline is 45-75 minutes.

Patient advice

  • Patients should be aware of the potential side effects such as: Dryness of the mouth, nose and throat; difficulty of swallowing and inhibition of sweating.
  • Parents should be warned of the potential for hyperthermia in small children, especially when they are overdressed.
  • Tasks requiring alertness and coordination should be avoided, because of the possible psychomotor impairment after the use of scopalamine.
Name Dosage Warnings/precautions and contraindications Adverse effects
Atropine sulphate Sol. Inj: 0.3- 1.2mg
I.M./I.V./S.C.
Tab 0.4-1.2 mg
W/P: Avoid overdose. Increased susceptibility to toxic effects in children.
Conventional dose may precipitate acute angle closure glaucoma in susceptible patients, convert partial organic pyloric stenosis into complete obstruction, lead to urinary retention in patients with prostatic
hypertrophy, formation of viscid plugs due to increased bronchial secretions in patients with chronic lung disease.
Contraindication: Hypersensitivity to atropine or other belladona alkaloids.
Dryness of mouth, nose, throat, skin; blurred vision, photophobia, tachycardia, palpitation, hyperthermia.
Glycopyrrolate Adults: inj range: 0.1-0.2 mg; Tab: 1-2mg
Pediatric: slon. inj. range: 4-10ug/kg upto 0.2 mg
W/P: May produce drowsiness or blurred vision; avoid operating machinery. Caution in elderly, autonomic neuropathy, renal and hepatic disease, ulcerative colitis, coronary heart disease, HTN.
Contraindicaiton:
Hypersensitivity to glycopyrrolate, acute closure glaucoma,
severe ulcerative colitis, unstable cardiovascular status in acute
hemorrhage, myasthenia gravis
Dryness of mouth, nose, throat, skin; blurred vision, tachycardia, palpitation, loss of taste, headache.
Pilocarpine hydrochloride Adults: Cancer patients: 15-30 mg/day;
Sjogren syndrome: 5mg qid.
W/P: Caution with significant cardiovascular disease, biliary tract disease, controlled
asthma, chronic bronchitis or COPD requiring
pharmacotherapy.
Monitor for toxicity and dehydration. May cause renal colic.
Contraindication:
Uncontrolled asthma, hypersensitivity to pilocarpine.
Sweating, nausea, xerostomia, rhinitis, chills, flushing, pharyngitis, HTn, bradycardia, tachycardia
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